This means it will give inaccurate results. The Cockcroft-Gault (CG) formula has not been expressed using standardized creatinine values.Why isn’t the Cockcroft-Gault formula recommended for clinical use? Both have been shown to be more accurate than the CG formula. The best way to determine drug dosing is with the CKD-EPI Creatinine Equation (2009) or the MDRD Study.It should not be used for drug dosing or to estimate GFR. The Cockcroft-Gault (CG) formula is provided on this website for research purposes only.SCr (serum creatinine) = mg/dL Why is the Cockcroft-Gault formula provided on this website? It's important to note that creatinine clearance is just one of several methods used to assess kidney function, and healthcare professionals may consider other factors, such as the estimated glomerular filtration rate (eGFR) or other diagnostic tests, in conjunction with creatinine clearance results to make comprehensive evaluations and treatment decisions related to kidney health.Calculate Results The Cockcroft and Gault formula (1973)Īdditional information The Cockcroft and Gault formula (1973)Ĭ Cr=x 0.85 (if female) Abbreviations/ Units It's important to note that creatinine clearance is just one of several methods used to assess kidney function, and healthcare professionals may consider other factors, such as the estimated glomerular filtration rate (eGFR) or other diagnostic tests, in conjunction with creatinine clearance results to make comprehensive evaluations and treatment decisions related to kidney health. Preoperative Evaluation: Prior to certain surgical procedures, especially those that may put additional stress on the kidneys or require the use of medications that are cleared by the kidneys, creatinine clearance may be measured to assess kidney function and determine the patient's ability to tolerate the procedure.Įvaluation of Kidney Transplant Recipients: Creatinine clearance is commonly used in the evaluation of potential kidney transplant recipients to assess their kidney function and determine their eligibility for transplantation. Creatinine clearance can help healthcare professionals determine the appropriate dosage of medications to ensure safety and efficacy. Medication Dosage Adjustment: Some medications, particularly those that are eliminated from the body through the kidneys, require dosage adjustments based on kidney function. It helps healthcare professionals determine the stage of CKD and make treatment decisions based on the severity of kidney impairment. The creatinine clearance test is often ordered in the following situations:Ĭhronic Kidney Disease (CKD) Monitoring: Creatinine clearance is used to monitor the progression of CKD and assess the level of kidney function over time. Instead, it is a diagnostic test used by healthcare professionals to assess kidney function and evaluate the severity of kidney disease. Why prescribe creatinine clearance?Ĭreatinine clearance is not typically prescribed as a medication or treatment. In some cases, more accurate methods such as nuclear medicine imaging or clearance tests using exogenous filtration markers may be used to directly measure GFR. However, it's important to note that creatinine clearance is an estimation and may not accurately represent the true GFR. It helps healthcare professionals determine the stage of CKD, make treatment decisions, adjust medication dosages, and evaluate the overall health of the kidneys. The calculated creatinine clearance value is expressed in milliliters per minute (mL/min) and provides an estimate of the volume of blood that is cleared of creatinine by the kidneys in a given time.Ĭreatinine clearance is used as an indicator of kidney function and is particularly useful in assessing the severity of chronic kidney disease (CKD) and monitoring its progression. The creatinine clearance test takes into account factors such as the individual's age, gender, and body size, as well as the creatinine levels in the urine and blood. By comparing the creatinine levels in both the urine and blood, the creatinine clearance can be calculated. The creatinine clearance test involves collecting a 24-hour urine sample and measuring the creatinine levels in the urine and blood. It is a calculated value that provides an estimate of how well the kidneys are filtering waste products, specifically creatinine, from the blood.Ĭreatinine is a waste product that is produced by the muscles and is normally filtered by the kidneys and excreted in urine. Creatinine clearance is a measurement used to estimate the glomerular filtration rate (GFR), which is a measure of kidney function.
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